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Search Result

Search Results for " checkpoint kinase (chk) "

11

Compounds

Cat No. Product Name Synonyms Targets
T6093 AZD-7762 AZD7762 Chk
AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
T7080 CCT245737 SRA737 Chk
CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).
T21331 SAR-020106 Chk
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.
T6350 CHIR-124 CHIR124,CHIR 124 Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
T2517 SCH900776 MK 8776,MK-8776 Chk , CDK
SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.
T6084 Rabusertib LY2603618,IC-83 Chk , PDK , Autophagy
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance...
T2033 BML-277 C 3742,Chk2 Inhibitor II,BML 277 Apoptosis , Chk
BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor.
T7300 GDC-0575 ARRY-575,RG7741 Chk
GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).
T4327 Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 Apoptosis , Chk , S6 Kinase
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
T4310 Prexasertib LY2606368 Apoptosis , Chk
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T6028 PF 477736 PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
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